The company entered an alliance with Scarecrow to develop an improved version of the Fear Toxin. Shortly after Scarecrow's escape, Simon Stagg ended up apprehended by the GCPD for his involvement in Scarecrow's plan. The recording of Stagg's canisters in the GCPD Lockup Evidence Room also implied that the company would suffer immensely for their role in Scarecrow's plan, with Aaron Cash stating that the canister "won't be the only thing confiscated [from Stagg Enterprises] tonight."
- Stagg Enterprises as well as its CEO were not native to the Batman Comics, but they were the main antagonists of the DC Comics franchise, Metamorpho.
- One of the victims of Professor Pyg in the Gotham's Most Wanted Side Mission, The Perfect Crime, Robert Kincaid, was a former microbiologist at the company, although he presumably fled after he was nearly made an assassination victim, presumably by Stagg to cover up some unethical research.